Quantitative analysis of EIN
Pathology services in the Western Norway Health Region – a center for applied digitization: Quantitative analysis of Endometrial Intraepithelial Hyperplasia/Neoplasia
Universitetsykehus i Nord Norge, avdeling for patologi
To train, test, validate and implement an application for automated, fast and reproducible method for EIN-scoring.
Endometrioid intraepithelial neoplasia (EIN) is a pre-malignant lesion of the uterine lining that predisposes to endometrioid endometrial adenocarcinoma (EEC). Correct diagnosis and management of EIN is becoming increasingly relevant with the rise in obesity, a well-established risk factor of EEC, in the population. Morphometric analysis called D-score, aims to provide a quantitative assessment of progression risk of premalignant endometrial lesions. Although it has been shown to be a reproducible measurement, adaption of the D-score is slow in laboratories, because it’s costly and timely. Despite the inclusion of EIN in WHO14 many pathologists still hold on to the original WHO94 definition both in diagnostics and research.
2020 - 2024