Quantitative analysis of EIN

Pathology services in the Western Norway Health Region – a center for applied digitization: Quantitative analysis of Endometrial Intraepithelial Hyperplasia/Neoplasia

Samarbeidspartnere

Universitetsykehus i Nord Norge, avdeling for patologi

Formål

Problemstilling

Endometrioid intraepithelial neoplasia (EIN) is a pre-malignant lesion of the uterine lining that predisposes to endometrioid endometrial adenocarcinoma (EEC). Correct diagnosis and management of EIN is becoming increasingly relevant with the rise in obesity, a well-established risk factor of EEC, in the population. Morphometric analysis called D-score, aims to provide a quantitative assessment of progression risk of premalignant endometrial lesions. Although it has been shown to be a reproducible measurement, adaption of the D-score is slow in laboratories, because it’s costly and timely. Despite the inclusion of EIN in WHO14 many pathologists still hold on to the original WHO94 definition both in diagnostics and research.